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3-star hotel

Residence Inn by Marriott Jacksonville-Mayo Clinic Area

Polished all-suite hotel with free Wi-Fi, breakfast, parking, and outdoor pool near Mayo Clinic and St. Johns Town Center in Jacksonville, FL.

4905 San Pablo Rd S, Jacksonville, FL 32224, United States View on map
9.2/10
Exceptional Based on 371 recent guest reviews
Free Wi-Fi Free breakfast Free parking Accessible Outdoor pool
What recent guests emphasize

Comfortable suites with attentive service and great amenities

Recent guests highlight spacious, well-equipped suites, friendly and attentive staff—especially at the bar and front desk—and a variety of complimentary amenities that enhance the stay.

Guests often praise

  • Spacious, clean, and comfortable suites featuring full kitchens and workspaces.
  • Friendly, attentive, and helpful staff, especially at the front desk and bar area.
  • Complimentary breakfast with a wide selection and thoughtful service before kitchen closing.
  • Inviting social spaces including a cozy patio and bar with knowledgeable bartenders.
  • Convenient free parking and pet-friendly policies adding extra value.

Worth knowing

  • No airport shuttle service available, though a shuttle to Mayo Clinic operates early morning.
  • Some guests noted a lack of bathtubs, which may be a drawback for those with special needs.
  • The gym is fully equipped and includes specialized equipment for guests with limited mobility.
  • Late check-out requests can be accommodated without extra charges if arranged in advance.
  • Bar and dining areas receive frequent positive mentions for both ambiance and service.

Best for

  • Visitors to Mayo Clinic needing convenient access and comfortable extended stays.
  • Groups or families looking for roomy suites with ample space to gather and relax.
  • Guests who appreciate a quiet atmosphere with relaxing social areas like patios and bars.
  • Travelers seeking hotels with complimentary breakfast and free parking included.
  • Those wanting pet-friendly accommodations and accessible facilities.
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About this property

Welcome to Residence Inn by Marriott Jacksonville-Mayo Clinic Area

Residence Inn by Marriott Jacksonville-Mayo Clinic Area offers comfortable all-suite accommodations suited for extended stays, especially for business travelers and visitors to the nearby Mayo Clinic. The hotel features polished units with kitchenettes, workspaces, and spacious layouts, allowing for a convenient blend of relaxation and productivity. Guests appreciate the cleanliness and thoughtful design, as reflected in reviews praising the comforting atmosphere and well-equipped rooms.

Facilities include a fitness center with specialized equipment, an outdoor pool, and a bar with attentive staff, creating an inviting environment for unwinding after a busy day. Complimentary breakfast is provided, featuring diverse options and accommodating takeout requests. While there is no airport shuttle, free parking and Wi-Fi services contribute to an accessible stay for both short- and longer-term visitors. The pet-friendly and smoke-free environment adds to the comfort of various guest needs.

Located at 4905 San Pablo Rd S, the hotel is situated in a lively area known for its proximity to golf courses, riverside parks, and retail centers like St. Johns Town Center. Nearby attractions such as TPC Sawgrass, Shipwreck Island Water Park, and the Beaches Museum offer options for leisure and sightseeing. The property is roughly a 30-minute drive from Jacksonville International Airport, making it suitable for travelers with convenient access to transportation.

Guest reviews highlight the friendly and attentive service from staff members, including personalized attention at the bar and front desk. Some praise the spaciousness of the suites and flexibility with check-out times, while others note the absence of amenities like a bathtub for those with specific needs. Overall, this hotel fits well for visitors seeking a practical, well-appointed extended stay experience near the Mayo Clinic and surrounding Jacksonville attractions.

Summary compiled by GoHotelly editors from verified guest reviews, partner descriptions and editorial notes.
Facilities & essentials

What's on-site and what you should know before you arrive

The short version: what's available day-to-day, and the key practical details most travelers search for.

Most popular facilities

Free Wi-Fi
Free breakfast
Free parking
Accessible
Outdoor pool
Air-conditioned
Business center
Pet-friendly
Restaurant
Fitness center
Smoke-free

Not available at this property

Airport shuttle
Verified guest reviews

What recent guests are actually saying

Reviews from travelers who stayed here in the last 12 months, grouped to help you spot the pattern quickly.

AJ
Alesha Johnson Apr 11, 2026
10

Recently, I had the pleasure of staying at this establishment and was thoroughly impressed by the exceptional service provided by the Michael and other front desk staff. Having visited this location on multiple occasions, it is always a welcome sight to encounter a familiar face. The accommodations were comfortable, cozy, and immaculate. The patio area is particularly inviting, providing a serene space to relax and unwind after a long week. During inclement weather, the stones illuminate, offering a gentle warmth. I highly recommend staying at this hotel again, particularly considering the absence of parking fees.

CA
Cynthia Asati Apr 02, 2026
10

4 girls celebrating one of us for her birthday and we were amazed how big those rooms were. The bathroom were big enough for all of us . We docorated the place and still had space to dance and enjoy. They had great aesthetics by the dining. They also had a bar omg and lots of sitting spaces with different ambiance. The location was perfect and safe.they had alot selection for breakfast, they even provide take out plates and bags. And before they close the kitchen they check each person if they need anything before they close. What an experience . And we requested if we can exit at 2pm and they were fine with no extra charges. We enjoyed the services, the rooms and the breakfast. I would recommend anyone to go there. I will sure come back.

MB
Matt Butler Apr 01, 2026
10

Mark and Taylor at the bar were fantastic. They educated us on the difference between an Old Fashioned and a Manhattan and they were so attentive. The front desk young lady, Q, was also so attentive and polite. We highly recommend this hotel to anyone staying in the Jacksonville area.

DJ
Deborah Jackson Mar 28, 2026
10

Great place to stay for trips to Mayo. They have a shuttle that leaves at 7AM to Mayo. Suites come more space, kitchenette and walk-in showers. Rooms are very clean!! Additionally, offer complimentary breakfast, have a bar area to order lunch/dinner foods and small store area for snacks.

DC
Diana Clements Mar 21, 2026
10

Great experience at The Residence Inn tonight. Great little bar restaurant with super personal attention. Taylor took great care of us. The food was surprisingly good. Mark made us great drinks. We were pleased with our service and our dinner.

GM
Gregory Mikell Feb 23, 2026
10

This has been one of the best experiences I've had at the Marriott hotels in recent years. I have an Executive Suite, which has a full kitchen with a full-size microwave, induction range, full-sized refrigerator, and a full corporate desk so that I can organize all of my business documents and rest comfortably. It even features a sleeper sofa, perfect for accommodating overnight guests. You actually get what you pay for. The only thing I wish that I had was a bathtub because I have chronic back pain, and I cannot do so in this suite

DP
david patterson Jan 26, 2026
10

From our early morning arrival through the days from the front desk too those who operate the shuttle, it has been an exemplary experience. One of the highlights of staying at the Residence Inn was the service provided by Taylor and Mark in the dining area. These are the kind of people that you hope to find as you travel to enhance and make your trip unforgettable.

LB
Leah Brooks Dec 30, 2025
10

Very convenient if visiting Mayo Clinic. Everything was nice, but I especially enjoyed the FULLY equipped gym, which even included a treatment table and a Nu Step for those with more limited mobility. The room was comfortable and clean, the breakfast was varied and fresh, and the staff was (mostly) kind and helpful.

Location & neighborhood

Where you'll find Residence Inn by Marriott Jacksonville-Mayo Clinic Area

Isle of Palms, Jacksonville, FL, USA

Vibrant area with golf courses, riverside parks & retail destinations like St. Johns Town Center.

  • Jacksonville International Airport 30 min Car
Things to do nearby

Worth the walk or a quick ride

Curated spots travelers usually pair with a stay in Florida. Distances are rough real-world times, not straight-line.

Shipwreck Island Water Park 1,263 reviews

Shipwreck Island Water Park

1944 Beach Blvd, Jacksonville Beach, FL 32250, United States

4.4 · Water Park
TPC Sawgrass 3,392 reviews

TPC Sawgrass

110 Championship Way, Ponte Vedra Beach, FL 32082, United States

4.8 · Golf Course
Beaches Museum 311 reviews

Beaches Museum

381 Beach Blvd, Jacksonville Beach, FL 32250, United States

4.8 · History Museum
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